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Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus

✍ Scribed by Lutful Kabir, Farruk M.; Agarwal, Payal; DeInnocentes, Patricia; Zaman, Jishan; Bird, Allison Church; Bird, R. Curtis


Book ID
118762496
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
721 KB
Volume
114
Category
Article
ISSN
0730-2312

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## Abstract Aberrant promoter methylation is an important mechanism for gene silencing. In the present study, 50 Barrett's esophagus‐associated esophageal adenocarcinomas (ADC), 50 cardiac ADC and 50 gastric ADC were investigated by means of methylation‐specific real‐time PCR for hypermethylation i