Novel drug-loaded gelatin films and their sustained-release performance

✍ Scribed by Mei Lin; Sheng Meng; Wei Zhong; Rui Cai; Qiangguo Du; Piotr Tomasik

• Book ID: 102299200
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 205 KB
• Volume: 90B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31366

✦ Synopsis

Abstract

A new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen‐loaded poly‐ε‐caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil‐in‐water emulsion followed by cross‐linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere‐film system were investigated. The results indicated that drug‐loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere‐film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009