Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-L-lactide)

✍ Scribed by U. Edlund; A.-C. Albertsson

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 233 KB
• Volume: 37
• Category: Article
• ISSN: 0887-624X
• DOI: 10.1002/(sici)1099-0518(19990615)37:12<1877::aid-pola17>3.0.co;2-4

✦ Synopsis

Novel microspheres from copolymers of 1,5-dioxepan-2-one (DXO) and Llactide (L-LA) were prepared by oil-in-water solvent evaporation and oil-in-oil solvent removal. The two preparation techniques were evaluated for sphere formulation and incorporation of two different drugs. Sustained release of these therapeutic substances was obtained. The consequences of altering the DXO : LA ratio, preparation method, and drug hydrophilicity were explored and identified as factors governing sphere quality, in vitro degradation, and drug release characteristics. We show that these relationships provide a powerful means of controlling the microsphere performance.