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Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

✍ Scribed by Kumar, Atul; Gupta, Garima; Srivastava, Suman; Bishnoi, Ajay Kumar; Saxena, Ruchi; Kant, Ruchir; Khanna, Ranjana S.; Maulik, Prakas R.; Dwivedi, Anila

Book ID
121389401
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
362 KB
Volume
3
Category
Article
ISSN
2046-2069

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A small library of novel benzocoumarin derivatives based on naturally occurring neo-tanshinlactone scaffold was constructed and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. A number of derivatives showed good anti-breast cancer activity, in some