Novel cytotoxic ring-a seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis

✍ Scribed by Gloria L. Silva; Roberto R. Gil; Baoliang Cui; Heebyung Chai; Thawatchai Santisuk; Ekarath Srisook; Vichai Reutrakul; Patoomratana Tuchinda; Smaisukh Sophasan; Suparp Sujarit; Suchart Upatham; Sean M. Lynn; John E. Farthing; Shi-Lin Yang; Jane A. Lewis; Melanie J. O'Neill; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A.Douglas Kinghorn

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 698 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01003-4

✦ Synopsis

A~~strac~: Coronalolide methyl ester (l), coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronuria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1-4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1. Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer ceti tines.Copyrighr 0 1996 Elsevier Science Ltd