Novel cytotoxic 1H-cyclopenta[b]benzofuran lignans from Aglaia elliptica

✍ Scribed by Baoliang Cui; Heebyung Chai; Thawatchai Santisuk; Vichai Reutrakul; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn

• Book ID: 104208253
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 638 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)10231-9

✦ Synopsis

Absrracr: Bioassay-guided fractionation of the stems and fruits of Aglaia elliptica using human oral epidermoid carcinoma (KB) cells, led to the isolation of five cyclopenta[b]benzofurans, constituted by methyl rocaglate (1) and four novel compounds (2-9, along with three known dammarane triterpenoids. Compound 5 possesses an unusual formyl ester substituent at the C-l position. The structures of the novel compounds were established on the basis of spectroscopic methods. Compounds l-5 were found to be very potent cytotoxic substances when evaluated against a panel of human cancer cell lines.