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Novel Cyclopropapyrroloindole Derivative (AT-3510) Bearing Methoxycarbonyl and Trifluoromethyl Groups

โœ Scribed by Fukuda, Yasumichi; Furuta, Hirosuke; Kusama, Yoshie; Ebisu, Hiroyuki; Oomori, Yasuo; Terashima, Shiro


Book ID
115446867
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
301 KB
Volume
42
Category
Article
ISSN
0022-2623

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Synthesis and antitumor activity of nove
โœ Yasumichi Fukuda; Yasuo Oomori; Yoshie Kusama; Shiro Terashima ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 255 KB

The title synthesis was achieved by employing oxidative cyclization of the enaminodiester prepared by Michael addition of the 5-aminoindoline with dimethyl acetylenedicarboxylate, as a key step. Some of these novel bis(methoxycarbonyl)cyclopropapyrroloindole (MC2CPI) derivatives 9c, d and their seco