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Novel compounds for the synthesis of cefdinir

✍ Scribed by K. V. V. Prasada Rao; Ramesh Dandala; Meenakshisunderam Sivakumaran; Ananta Rani; A. Naidu

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
417 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Preparation of two new compounds 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazolyl‐(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐trityloxyiminoacetate (14) and 2‐mercapto‐5‐methyl‐1, 3,4‐thiadiazolyl‐ (Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐acetyloxyiminoacetate (12) and their use in the preparation of 7β‐[(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐hydroxyiminoacetamido]‐3‐vinylcephem‐4‐carboxylic acid, also known by the generic name Cefdinir (1) has been accomplished in a single step by coupling with 7‐amino‐3‐vinylcephem‐4‐carboxylic acid (7) with purity of greater than 99% by HPLC.

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