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Novel Chromene Derivatives as TNF-α Inhibitors.

✍ Scribed by Jie-Fei Cheng; Akira Ishikawa; Yoshinori Ono; Thomas Arrhenius; Alex Nadzan


Book ID
101954177
Publisher
John Wiley and Sons
Year
2004
Weight
91 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Novel TNF-α converting enzyme (TACE) inh
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Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK pr