Novel CCR1 antagonists with improved metabolic stability
โ Scribed by Matthew F Brown; Mike Avery; William H Brissette; J.H Chang; Kevin Colizza; Maryrose Conklyn; Amy P DiRico; Ronald P Gladue; John C Kath; Suzanne S Krueger; Paul D Lira; Brett M Lillie; Greg D Lundquist; Erin N Mairs; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; Michelle I Rossulek; Richard M Shepard; Jeff Sims; Timothy J Strelevitz; Susan Truesdell; Laurie A Tylaska; Kwansik Yoon; Deye Zheng
- Book ID
- 108073258
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 272 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0960-894X
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๐ SIMILAR VOLUMES
A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability