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Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues

✍ Scribed by Carmen Balo; Franco Fernández; Evangelina Lens; Carmen López; Graciela Andrei; Robert Snoeck; Jan Balzarini; Erik De Clercq

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
339 KB
Volume
330
Category
Article
ISSN
0365-6233

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✦ Synopsis

cis-3-Aminomethylcyclopentylmethanol (4) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8-azahypoxanthine, uracil, and 5-iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.

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