Novel Biodegradable Pyridinium Amphiphiles for Gene Delivery
✍ Scribed by Dirk Pijper; Erna Bulten; Jarmila Šmisterová; Anno Wagenaar; Dick Hoekstra; Jan B. F. N. Engberts; Ron Hulst
- Book ID
- 102169967
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 173 KB
- Volume
- 2003
- Category
- Article
- ISSN
- 1434-193X
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Nonviral gene delivery remains an outstanding challenge to the scientific community. [1] Fifteen years of interdisciplinary effort since the introduction of cationic amphiphiles for DNA and RNA transfection by Felgner et al. [2] compare to millions of years of evolutionary optimization of the compet
## Abstract For Abstract see ChemInform Abstract in Full Text.
A new biodegradable polyphosphoester, poly[[(cholesteryl oxocarbonylamido ethyl) methyl bis(ethylene) ammonium iodide] ethyl phosphate] (PCEP) was synthesized and investigated for gene delivery. Carrying a positive charge in its backbone and a lipophilic cholesterol structure in the side chain, PCEP