𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel Biodegradable and Thermosensitive Dex-AI/PNIPAAm Hydrogel

✍ Scribed by Xian-Zheng Zhang; Da-Qing Wu; Guo-Ming Sun; Chih-Chang Chu

Book ID
102467854
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
132 KB
Volume
3
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The dextran‐allyl isocyanate/poly(N‐isopropylacrylamide) (Dex‐AI/PNIPAAm) hydrogel was designed and prepared by copolymerization of the modified dextran with N‐isopropylacrylamide (NIPAAm). This novel Dex‐AI/PNIPAAm hydrogel is biodegradable and intelligent due to its biodegradable dextran linkage and thermosensitive PNIPAAm moiety. With an increase in dextran content, it exhibits the increased lower critical solution temperature (LCST) and decreased porous microstructure. Also, the thermosensitivity of this hydrogel is also controllable and adjustable depending on the different compositions.

SEM micrographs of the Dex‐AI/PNIPAAm hydrogels.

magnified imageSEM micrographs of the Dex‐AI/PNIPAAm hydrogels.

📜 SIMILAR VOLUMES

Synthesis, characterization and controll
Synthesis, characterization and controlled drug release of thermosensitive IPN–PNIPAAm hydrogels
✍ Xian-Zheng Zhang; Da-Qing Wu; Chih-Chang Chu 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 744 KB

A method was developed to prepare thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels with an interpenetrating polymer network (IPN) structure for the purpose of improving its mechanical properties, response rate to temperature and sustained release of drugs. Although the differential sc

Fabrication and characterization of a no
Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release
✍ Xiao-Ding Xu; Hua Wei; Xian-Zheng Zhang; Si-Xue Cheng; Ren-Xi Zhuo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

## Abstract Novel composite poly(__N__‐isopropylacrylamide) (PNIPAAm) hydrogels, containing poly(__N__‐isopropylacrylamide)‐__block__‐poly(methyl methacrylate) (PNIPAAm‐__b__‐PMMA) micelles for sustained drug delivery were prepared and characterized. Various amounts of thermal sensitive PNIPAAm‐__b