Novel Bioactive Steroidal Alkaloids from Pachysandra procumbens

✍ Scribed by Leng Chee Chang; Krishna P.L Bhat; Harry H.S Fong; John M Pezzuto; A.Douglas Kinghorn

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 107 KB
• Volume: 56
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(00)00232-5

✦ Synopsis

AbstractÐ(1)-(20S)-20-(Dimethylamino)-3a-(methylbenzoylamino)-11-methylene-5a-pregnane (1), a steroidal alkaloid with a new substitution pattern, was isolated from the entire plant of Pachysandra procumbens, together with four other new steroidal alkaloids, ( 1) 1)-(20S)-20-(dimethylamino)-3a-(methylbenzoylamino)-5a-pregn-12b-yl acetate (4), and ( 1)-(20S)-20-(dimethylamino)-3a-(methylsenecioylamino)-5a-pregn-12b-ol (5), as well as two known compounds, (1)-pachysamine H ( 6) and (1)pachysandrine B (7). The structures of the new compounds were determined by spectroscopic methods. Compounds 1±7 were evaluated for their potential cancer chemopreventive properties using an in vitro estrone sulfatase assay.