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Novel Binding and Efficient Cellular Uptake of Guanidine-Based Peptide Nucleic Acids (GPNA)

✍ Scribed by Zhou, Peng; Wang, Miaomiao; Du, Lei; Fisher, Gregory W.; Waggoner, Alan; Ly, Danith H.


Book ID
120505672
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
72 KB
Volume
125
Category
Article
ISSN
0002-7863

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## Abstract A 12‐mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell‐penetrating features. The cellular uptake and the antisense activity of these conjugates were assessed in parallel. Quantitatio