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Novel Basic Isoflavones as Inhibitors of Bone Resorption

✍ Scribed by Maurizio Delcanale; Gabriele Amari; Elisabetta Armani; Milco Lipreri; Maurizio Civelli; Elisabetta Galbiati; Massimo Giossi; Paola Lorenza Caruso; Patrizia Crivori; Pierre-Alain Carrupt; Bernard Testa

Publisher: John Wiley and Sons
Year: 2001
Tongue: German
Weight: 137 KB
Volume: 84
Category: Article
ISSN: 0018-019X
DOI: 10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n

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✦ Synopsis

A number of aminoalkoxy analogues of ipriflavone ( 7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 ± 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active.

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