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Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis

✍ Scribed by Shigeaki Suzuki; Takashi Satoh; Hidekata Yasuoka; Yasuhito Hamaguchi; Kortaro Tanaka; Yutaka Kawakami; Norihiro Suzuki; Masataka Kuwana


Book ID
113729705
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
251 KB
Volume
170
Category
Article
ISSN
0165-5728

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We have cloned a novel voltage-gated K channel, LKv1, in two species of leech. The properties of LKv1 expressed in transiently transfected HEK293 cells is that of a delayed rectifier current. LKv1 may be a major modulator of excitability in leech neurons, since antibody localization studies show tha