Novel Asymmetric Wittig Reaction: Synthesis of Chiral Allenic Esters.
β Scribed by Teresa M. V. D. Pinho e Melo; Ana L. Cardoso; Antonio M. d'A. Rocha Gonsalves; Joao Costa Pessoa; Jose A. Paixao; Ana M. Beja
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The first asymmetric reaction catalyzed by chiral spiroborated esters with an O~3~BN framework was reported. In the presence of 0.1 equivalent of (__R,S__)β1 or (__S,S__)β1, acetophenone was reduced by 0.6 equivalent of borne in THF at 0β5 Β°C for 2 h to give (R)β1βphenylethanol of up to
Scheme 1. Desymmetrizing imine formation by amine equivalent "NH 2 " for the construction of quaternary asymmetric centers. Scheme 2. Asymmetric aza-Wittig reactions mediated by chiral phosphorus(III) reagents 4.