We used two mouse models of Huntington's disease (HD) to examine changes in glutamate receptor sensitivity and striatal electrophysiology. One model, a transgenic, consisted of mice expressing exon 1 of the human HD gene and carrying 141-157 CAG repeat sequences (R6/2 line). The second model, a CAG
Novel approach to studying N-methyl-D-aspartate receptor function in the kindling model of epilepsy
β Scribed by James O. McNamara; Douglas W. Bonhaus; J. Victor Nadler
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 649 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The organochlorine pesticide dieldrin is a persistent organic pollutant that accumulates in the fatty tissue of living organisms. In mammals, it antagonizes the GABA(A) receptor, producing convulsions after acute exposure. Although accumulation in human brain has been reported, little is known about
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects primarily the striatum and cerebral cortex. A search for the factors that increase the vulnerability of striatal neurons will lead to a better understanding of the pathological cascades of this disease. A curr
The associative avian forebrain region medio-rostral neostriatum/hyperstriatum ventrale (MNH) is involved in auditory filial imprinting and may be considered the avian analogue of the mammalian prefrontal cortex. In search of the neurochemical and physiological mechanisms which play a role in this l