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Novel antimigraineur dotarizine releases Ca2+ from caffeine-sensitive Ca2+ stores of chromaffin cells

✍ Scribed by Jesús Novalbos; Francisco Abad-Santos; Pedro Zapater; Javier Alvarez; María Teresa Alonso; Mayte Montero; Antonio G García


Book ID
110004592
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
198 KB
Volume
128
Category
Article
ISSN
0007-1188

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A considerable fraction of freshly prepared hepatocytes loaded with the fluorescent [Ca2 + Ii indicator fura-2 exhibited spontaneous rhythmic fluctuations that tended to decrease with increasing length of incubation after isolation. These oscillations were dependent on the external Ca2 +. They could