Novel Anti-Inflammatory Constituents of Artocarpus rigida

✍ Scribed by Yi-Huang Lu; Chun-Nan Lin; Horng-Huey Ko; Sheng-Zehn Yang; Lo-Ti Tsao; Jih-Pyang Wang

• Book ID: 102255204
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 102 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390207

✦ Synopsis

Abstract

A novel phenolic compound containing an oxepine ring, artocarpol I (1), and a new biphenylpropanoid, artocarpol J (2), were isolated from the root bark of Artocarpus rigida. The structures, including relative configurations, were elucidated by spectroscopic data. Compound 1 and artocarpol J peracetate (3) strongly inhibited in a concentration‐dependent manner the formyl‐Met‐Leu‐Phe (fMLP)/cytochalasin B (CB)‐stimulated superoxide anion formation in neutrophils with IC~50~ values of 17.1±0.40 and 20.5±2.60 μM, respectively. Biogenetically, all the novel phenolic compounds isolated from this plant seem to be derived from stilbene.