Novel anti-angiogenic peptides derived From ELR-containing CXC chemokines
✍ Scribed by Emmanouil D. Karagiannis; Aleksander S. Popel
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 440 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Abstract
Angiogenesis is tightly regulated by numerous endogenous pro‐ and anti‐angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro‐angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22–24‐amino acid peptides derived from the pro‐angiogenic ELR‐containing CXC chemokines exhibit notable anti‐proliferative and anti‐migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro‐angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis. J. Cell. Biochem. 104: 1356–1363, 2008. © 2008 Wiley‐Liss, Inc.