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NOVEL ANIMAL MODELS FOR STUDYING SCHIZOPHRENIA: BAC-DRIVEN MIRNA-MEDIATED IN VIVO SILENCING OF GENE EXPRESSION

✍ Scribed by Karoly Mirnics


Book ID
119364463
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
62 KB
Volume
117
Category
Article
ISSN
0920-9964

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Novel animal models for studying complex
✍ Garbett, K A; HorvΓ‘th, S; Ebert, P J; Schmidt, M J; Lwin, K; Mitchell, A; Levitt πŸ“‚ Article πŸ“… 2010 πŸ› Nature Publishing Group 🌐 English βš– 729 KB

In schizophrenia, glutamic acid decarboxylase 1 (GAD1) disturbances are robust, consistently observed, cell-type specific and represent a core feature of the disease. In addition, neuropeptide Y (NPY), which is a phenotypic marker of a sub-population of GAD1-containing interneurons, has shown reduce