𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel and variant ribozymes obtained through in vitro selection

✍ Scribed by Tao Pan


Book ID
104414979
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
763 KB
Volume
1
Category
Article
ISSN
1367-5931

No coin nor oath required. For personal study only.

✦ Synopsis


Ribozymes are RNA molecules capable of catalyzing chemical reactions. Natural ribozymes generally accelerate the rate of cleavage and ligation of specific phosphodiester bonds. In vitro selection of RNA is now being used as a powerful technique to isolate novel and variant ribozymes that carry out catalysis at phosphodiester and carbon bonds. The range of reactions catalyzed by in vitro selected ribozymes is now well beyond the scope of known natural ribozymes.


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Variant generation and selection: An In
✍ Donna A. Chow πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 French βš– 549 KB

## Abstract Evidence for a new __in vitro__ model of tumor progression was sought on the basis of the variant generation and selection hypothesis. The stability of a cloned murine tumor was examined during growth in standard tissue culture or in media containing the tumor promoter 12–0‐tetradecanoy