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Novel and Potent 3-(2,3-Dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 Antagonists.

✍ Scribed by William A. Carroll; Douglas M. Kalvin; Arturo Perez-Medrano; Alan S. Florjancic; Ying Wang; Diana L. Donnelly-Roberts; Marian T. Namovic; George Grayson; Prisca Honore; Michael F. Jarvis


Book ID
102006010
Publisher
John Wiley and Sons
Year
2007
Weight
24 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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📜 SIMILAR VOLUMES


4-(3-Nitro­benzyl­ideneamino)-3-(1H-1,2,
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In the title compound, C~12~H~10~N~8~O~2~S, the triazole and benzene rings make dihedral angles of 72.16 (2) and 7.39 (3)°, respectively, with the thione-substituted triazole ring. In the crystal structure, intermolecular N—H...N hydrogen bonds link the molecules into chains running in the [101] dir

4-(2,4-Di­chloro­benzyl­amino)-3-phenyl-
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The title compound, C 22 H 18 Cl 2 N 4 , displays the characteristic features of 1,2,4-triazole derivatives. There is an NÐHÁ Á ÁN intermolecular hydrogen bond.

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The title compound, C 15 H 13 N 3 S, was prepared by the reaction of 1-(2-chloroethyl)benzene with hydrazine and phenyl isothiocyanate. Packing is stabilized by N-HÁ Á ÁS intermolecular hydrogen bonds and C-HÁ Á Á interactions.