Novel and Highly Effective Method for the Trimethylsilylation of Alcohols and Phenols with Hexamethyldisilazane (HMDS), Catalyzed by I2 Generated in situ Using Fe(NO3)3⋅9 H2O/NaI under Heterogeneous and Neutral Conditions

✍ Scribed by Ardeshir Khazaei; Sadegh Rahmati; Amin Rostami

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 152 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900002

✦ Synopsis

Abstract

Structurally diverse alcohols and phenols were trimethylsilylated in a clean and efficient reaction with hexamethyldisilazane (HMDS) based on the use of I~2~ generated in situ from Fe(NO~3~)~3~⋅9 H~2~O/NaI. The reaction occurs very rapid in good‐to‐high yield in CH~2~Cl~2~ at room temperature, and the use of toxic and corrosive molecular I~2~ is avoided.