Novel amphiphilic ternary polysaccharide derivates chitosan-g- PCL-b-MPEG: Synthesis, characterization, and aggregation in aqueous solution
✍ Scribed by Yiye Lu; Li Liu; Shengrong Guo
- Book ID
- 101723176
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2007
- Tongue
- English
- Weight
- 251 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Abstract
Chitosan‐g‐PCL‐b‐MPEG copolymers of various compositions were successful synthesized via a protection‐graft‐deprotection procedure, by the esterification of phthaloyl‐protected chitosan (PHCS) with MPEG‐b‐PCL‐COOH, which was synthesized from MPEG and ε‐caprolactone and carboxylated by maleic anhydride. The chemical structure of the chitosan‐g‐PCL‐b‐MPEG was characterized by Fourier transform infrared and NMR spectroscopy. The chitosan‐g‐PCL‐b‐MPEG was obtained as amphoteric hybrid with amino polysaccharide backbone and amphiphilic MPEG‐b‐PCL side chain. Their crystallinity and aggregation behavior in aqueous solution were also investigated. © 2007 Wiley Periodicals, Inc. Biopolymers 86: 403–408, 2007.
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