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Novel Amphiphilic Degradable Poly(ε-caprolactone)-graft-poly(4-vinyl pyridine), Poly(ε-caprolactone)-graft-poly(dimethylaminoethyl methacrylate) and Water-Soluble Derivatives

✍ Scribed by Benjamin Nottelet; Michel Vert; Jean Coudane

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
230 KB
Volume
29
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

New amphiphilic graft copolymers that have a poly(ε‐caprolactone) (PCL) biodegradable hydrophobic backbone and poly(4‐vinylpyridine) (P4VP) or poly(2‐(N,__N‐__dimethylamino)ethyl methacrylate) (PDMAEMA) hydrophilic side chains have been prepared by anionic polymerization of the corresponding 4VP and DMAEMA monomers using a PCL‐based macropolycarbanion as initiator. The water solubility of these amphiphilic copolymers is improved by quaternization, which leads to fully water‐soluble cationic copolymers that give micellar aggregates in deionized water with diameters ranging from 65 to 125 nm. In addition, to improve the hydrophilicity of PCL‐g‐P4VP, grafting of poly(ethylene glycol) (PEG) segments has been carried out to give a water‐soluble double grafted PCL‐g‐(P4VP;PEG) terpolymer.

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## Abstract A novel block copolymer, poly(ε‐caprolactone)‐__b__‐poly(4‐vinyl pyridine), was synthesized with a bifunctional initiator strategy. Poly(ε‐caprolactone) prepolymer with a 2,2,6,6‐tetramethylpiperidinyloxy (TEMPO) end group (PCL~T~) was first obtained by coordination polymerization, whic