## Abstract The differentiating and antitumor activities of 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) in vitro and 1α‐hydroxyvitamin D~3~ (1α(OH)D~3~) in vivo were studied with a human osteosarcoma cell line (OST strain). Antitumor activity was estimated with the use of 3‐(4,5‐dimethylthiazol)
✦ LIBER ✦
‘Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities’
✍ Scribed by Aimee R. Usera; Patrick Dolan; Thomas W. Kensler; Gary H. Posner
- Book ID
- 108072666
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 312 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0968-0896
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The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1