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Novel agents and strategies for treatment of p53-defective chronic lymphocytic leukemia

โœ Scribed by Michael R. Grever; David M. Lucas; Amy J. Johnson; John C. Byrd


Book ID
119195377
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
114 KB
Volume
20
Category
Article
ISSN
1521-6926

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p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with