𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel Acetogenins from the Leaves of Dasymaschalon sootepense

✍ Scribed by Andrea Sinz; Rudolf Matusch; Thomas Kämpchen; Winfried Fiedler; Jürgen Schmidt; Thawatchai Santisuk; Sirichai Wangcharoentrakul; Suttiporn Chaichana; Vichai Reutrakul

Publisher
John Wiley and Sons
Year
1998
Tongue
German
Weight
118 KB
Volume
81
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

The hexane extract from the leaves of Dasymaschalon sootepense Craib ( Annonaceae) showed strong cytotoxic activity against the L1210 tumor cell line. Activity-directed fractionation of the extract by column chromatography on silica gel and high-pressure liquid chromatography led to the isolation of the acetogenins 1 ± 4 as the main active principles. The structures of the two novel structures named sootepensin A (1) and sootepensin B (2) were elucidated by spectroscopic analysis ( UV, EI-and ESI-MS, 1D-and 2D-1 H-and 13 C-NMR ). The absolute configurations were established by 2D-NMR experiments utilizing Mosher esters. Two recently described compounds, tonkinin C (3) and tonkinesin C (4), were also isolated and are new to the genus Dasymaschalon. All four acetogenins were found to be highly cytotoxic against the L1210 tumor cell line.

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel Acetogenins f
ChemInform Abstract: Novel Acetogenins from the Leaves of Dasymaschalon sootepense.
✍ A. SINZ; R. MATUSCH; T. KAEMPCHEN; W. FIEDLER; J. SCHMIDT; T. SANTISUK; S. WANGC 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Three Minor Novel T
ChemInform Abstract: Three Minor Novel Triterpenoids from the Leaves of Diospyros kaki
✍ Guang Chen; Zong-Quan Wang; Ji-Ming Jia 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 20 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v