## Abstract magnified image A tandem MichaelβS~N~Ar annulation reaction has been developed for the synthesis of 1βalkylβ2,3βdihydroβ4(1__H__)βquinolinones. Success in the reaction followed expected electronic effects for the final S~N~Ar ring closure. Treatment of doubly activated 1β(2βfluoroβ5βni
β¦ LIBER β¦
Novel [3+2] and [3+3] 4-quinolone annulations by tandem Claisen-Cope amidoalkylation reaction
β Scribed by Newhouse, Bradley J.; Bordner, Jon; Augeri, David J.; Litts, Christopher S.; Kleinman, Edward F.
- Book ID
- 127392341
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 631 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
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## Abstract magnified image A series of 2β(2βnitrobenzyl)βsubstituted Ξ²βketo ester derivatives has been subjected to reductive cyclization under catalytic hydrogenation conditions. The reactions were found to be highly dependent on the catalyst and hydrogen pressure used. Hydrogenation over 5% pal