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Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor: N-benzyl modifications

✍ Scribed by Izzy Boyfield; Martyn C. Coldwell; Michael S. Hadley; Maureen A.M. Healy; Christopher N. Johnson; David J. Nash; Graham J. Riley; Emma E. Scott; Stephen A. Smith; Geoffrey Stemp

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 205 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00621-x

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✦ Synopsis

A series of 2,5-disubstituted-lH-pyrroles (4 -26) has been prepared where the conformational requirements of the N-ethyl, N-benzyl side-chain of 1 and the effect of introducing substituents into the benzyl group have been investigated. The (R)<z-methylbenzyl 6 and aminoindane 10 side-chains retained high ',fffinity for the dopamine D 3 receptor, 'although neither showed the selectivity of 2-phenylazacycloheptane 2.

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