Novel 1,1,3-Trioxo-2 H ,4 H -thieno[3,4- e ][1,2,4]thiadiazine Derivatives as Non-Nucleoside Reverse Transcriptase Inhibitors That Inhibit Human Immunodeficiency Virus Type 1 Replication
✍ Scribed by Arranz, Esther; Díaz, Juan A.; Ingate, Simon T.; Witvrouw, Myriam; Pannecouque, Christophe; Balzarini, Jan; De Clercq, Erik; Vega, Salvador
- Book ID
- 126968087
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 182 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
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AbstractÐBenzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to aord active inhibitors, with the most potent compound exhibiting an IC 90 =180 nM in a whole cell assay. The 2,2dioxide-1H-2,1,3-benzothiadiazine ring system was con
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