✦ LIBER ✦

Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their use for the Synthesis of Fluoroquinolones

✍ Scribed by Alexander Ya. Aizikovich; Maxim V. Nikonov; Michael I. Kodess; Vladislav Yu. Korotayev; Valery N. Charushin; Oleg N. Chupakhin

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 97 KB
Volume: 56
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(00)00107-1

No coin nor oath required. For personal study only.

✦ Synopsis

A common approach to the synthesis of 1-trifluoromethyl-1,2-ethylenediamines was developed. Based on these original building blocks the new derivatives of N-substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7 J F-F between the trifluoromethyl group and F-8 were measured in the 19 F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19 F{ 19 F} double resonance technique.

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel 1-Trifluorome

ChemInform Abstract: Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their Use for the Synthesis of Fluoroquinolones.

✍ Alexander Ya. Aizikovich; Maxim V. Nikonov; Michael I. Kodess; Vladislav Yu. Kor 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: Use of 1,3-Dipolar

ChemInform Abstract: Use of 1,3-Dipolar Cycloaddition for the Synthesis of Novel Fluoroquinolones.

✍ N. N. NAGIBINA; L. P. SIDOROVA; N. A. KLYUEV; V. N. CHARUSHIN; O. N. CHUPAKHIN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

Use of 1,3-Dipolar Cycloaddition for the Synthesis of Novel Fluoroquinolones. -A novel synthetic way for the modification of 6-fluoroquinoline-4-one-3-carboxylic acids is presented. The 7-azido-derivative (II) undergoes 1,3-dipolar cycloaddition to several alkenes like norbornene, cyclopentenonorbo

ChemInform Abstract: Synthesis of Some N

ChemInform Abstract: Synthesis of Some Novel (1-Substituted-5-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)-(substituted benzothiazol-2-yl)-diazene and Their Antifungal Activity.

✍ V. Sareen; V. Khatri; D. Shinde; S. Sareen 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

ChemInform Abstract: 1-Bromo-2-trifluoro

ChemInform Abstract: 1-Bromo-2-trifluoroacetylcyclobutenes as Novel Building Blocks for the Construction of Trifluoromethyl Substituted Heterocycles. Part 1. Synthesis of 5-(Trifluoromethyl)-2(5H)-furanones Condensed with Substituted Cyclobutenes.

✍ Andrey B. Koldobskii; Nikolay P. Tsvetkov; Ekaterina V. Solodova; Valery N. Kali 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Synthesis of Novel 1-Aryl-Substituted 8-

Synthesis of Novel 1-Aryl-Substituted 8-Methoxynaphthalenes and Their Tendency for Atropisomerization.

✍ Seiji Yoshikawa; Jun-ichi Odaira; Yuki Kitamura; Ashutosh V. Bedekar; Takumi Fur 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 160 KB

ChemInform Abstract: 1-Bromo-2-trifluoro

ChemInform Abstract: 1-Bromo-2-trifluoroacetylcyclobutenes as Novel Building Blocks for the Construction of Trifluoromethyl Substituted Heterocycles. Part 2. Synthesis of Trifluoromethyl Substituted Thiophenes, Condensed with Cyclobutene Moieties.

✍ Andrey B. Koldobskii; Nikolay P. Tsvetkov; Ekaterina V. Solodova; Valery N. Kali 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views