✦ LIBER ✦
Notiz zur Synthese Eines Optisch Aktiven Ace-Hemmers mit Amino-oxo-benzazepin-1-alkansäure-Struktur mittels enantiokonvergierender kristallisationsinduzierter Racemat-Trennung
✍ Scribed by Stephen K. Boyer; Rolland A. Pfund; Robert E. Portmann; Gottfried H. Sedelmeier; Hansjürg F. Wetter
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- German
- Weight
- 433 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Note on the Synthesis of an Optically Active ACE Inhibitor with Amino-0x0-henzazepine-1-alkanoic-Acid
Structure by Means of an Enantioconvergent Crystallization-Based Resolution
An enantioselective synthesis of the potent angiotensin-converting enzyme inhibitor (I'S,3S)-3-[( 1'-(ethoxycarbonyl)-3'-phenylpropyl)amino]-2,3,4,5-tetrahydro-2-0~0-1~~ I-benzazepine-I-acetic acid hydrochloride (3) is described which uses a crystallization-based resolution of a racemic amino intermediate with concomitant racemization ofthe unwanted enantiomer.