Enzymatic preparation of homochiral 2-is
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Beat Wirz; Milan Soukup
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Article
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1997
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Elsevier Science
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English
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An efficient enzymatic procedure for the enantio-and regioselective monohydrolysis of diethyl 2-isobutyl succinate 3 using subtilisin Carlsberg has been developed. The product (R)-2-isobutyl succinic acid 4-ethyl ester 4, a collagenase inhibitor building block, was obtained in high enantiomeric exce