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Notes- Malonic Ester Synthesis of δ-Aminolevulinic Acid. The Reaction of N-3-Bromoacetonylphthalimide with Malonic Ester

✍ Scribed by Tschudy, Donald; Collins, Annie

Book ID
111658731
Publisher
American Chemical Society
Year
1959
Tongue
English
Weight
276 KB
Volume
24
Category
Article
ISSN
0022-3263

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Synthesis of the 2-ethyl-3-methylsuccini
Synthesis of the 2-ethyl-3-methylsuccinic acids via a stereospecific malonic ester alkylation
✍ F. F. van Leeuwen; A. Noordam; L. Maat; H. C. Beyerman 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 476 KB

## Abstract Reaction of (−)‐(__S__)‐methyl 2‐bromopropionate (**4**) (obtained from l‐alanine) with dibenzyl ethylmalonate gave stereospecifically in four steps ( + )‐(2__R__,3__S__)‐2‐ethyl‐3‐methylsuccinic acid (**8a**) and its diastereoisomer (**8b**). The malonic ester alkylation proceeded with