𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Note on linkage analysis when the mode of transmission is unknown

✍ Scribed by Rosalind J. Neuman; John P. Rice; D. C. Rao

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
572 KB
Volume
7
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

A major difficulty in a linkage analysis arises from the necessity of specifying the mode of inheritance prior to analysis. For a complex disease, such as those encountered in psychiatric illnesses, the mode of inheritance is generally not known in advance. Consequently, some estimation procedure is often combined with linkage analysis to circumvent this. We discuss several precautions that should be taken when using traditional statistical testing methods: correction of the likelihood for the method of sampling families and the computation of the lod score. We analyze simulated data with pedigrees selected under a sampling scheme approximating single ascertainment. In this situation, the severity of the above problems is attenuated.

πŸ“œ SIMILAR VOLUMES

Performance of linkage analysis under mi
Performance of linkage analysis under misclassification error when the genetic model is unknown
✍ Dr. Maria Martinez; Myriam Khlat; Marion Leboyer; FranΓ§oise Clerget-Darpoux πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 316 KB

Linkage analysis of complex diseases raises a number of important methodological problems. One of them concerns the clinical classification of disease phenotypes. In this study, we investigate the effects of false positive misclassification on the estimation of the recombination fraction and on the

A Note on the Analysis of the Two-Period
A Note on the Analysis of the Two-Period Crossover Design When the Period-Treatment Interaction is Significant
✍ A. P. Grieve πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 250 KB πŸ‘ 2 views

In the analysis of a two-period cro88over study GBIZZLE (1965) suggeata that, if a preliminary k t for a period by treatment inbraction (residual effeot, carryover effect) fsignificant at the 10 o/o level, the direct effects of the treatments should be compared by performix$ a t -h t on the data fro

On the asymptotic behavior of the estima
On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified
✍ Dr. John A. Williamson; Christopher I. Amos πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 535 KB

We show that under the null hypothesis of no linkage the maximum likelihood estimator of the recombination fraction converges to 1/2 even when the trait-related parameter values in the likelihood function are misspecified. Furthermore, we show that under the null hypothesis of no linkage, but with m