In multiple essays a 'Standard' preparation is compared in a single assay with two or more 'Test' preparations (FINNEY, 1978, ch. 11). I n addition to the estimation of the relative potency of the 'Test' preparations the question arises as to simultaneous confidence limits, or else a joint confidenc
Note on Confidence Regions in Multiple Assays
โ Scribed by Prof. B. M. Bennett
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 103 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0323-3847
No coin nor oath required. For personal study only.
โฆ Synopsis
This note is in continuation of the author's reaulte on 'classical' confidence regions for relative potencies in multiple assays (BENNEIT, 1987). I t is shown by the use of a Bonferroni inequality (e.g. MILLER, ch. 2, 1980) that approximata confidence regions for the relative potencies {Mc} i = l , ...,p may also be obtained directly. A comparison with the classical regions is made for the case: p = 2 using Finney's example (1978, ch. 2).
๐ SIMILAR VOLUMES
Let {e,, ..., e k } be the potencies of k' substances relative to a standard in a multiple dilution asray. Joint confidence bounds for these are given with confidence coefficient a t leaat l-a. These bounds are easily interpreted; they appeal to available tables; they improve Scheffe's bounds; they