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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

✍ Scribed by Keiki Kumano; Shigeru Chiba; Atsushi Kunisato; Masataka Sata; Toshiki Saito; Etsuko Nakagami-Yamaguchi; Tomoyuki Yamaguchi; Shigeo Masuda; Kiyoshi Shimizu; Tokiharu Takahashi; Seishi Ogawa; Yoshio Hamada; Hisamaru Hirai


Book ID
117723375
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
724 KB
Volume
18
Category
Article
ISSN
1074-7613

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## Abstract We have addressed the hypothesis that Notch ligands play a decisive role in determining the ability of antigen‐presenting cells to influence T cell polarization. Dendritic cells displayed distinct expression profiles of Delta and Jagged ligands for Notch when exposed to biologically rel