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Notch signaling as a therapeutic target for breast cancer treatment?

โœ Scribed by Jianxun Han; Michael J Hendzel; Joan Allalunis-Turner


Book ID
118726754
Publisher
BioMed Central
Year
2011
Tongue
English
Weight
412 KB
Volume
13
Category
Article
ISSN
1465-5411

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Notch signaling as a therapeutic target
โœ Yunsun Nam; Jon C Aster; Stephen C Blacklow ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 249 KB

Signals transduced by Notch receptors influence differentiation and proliferation in a wide variety of cell types. Activation of a Notch signal by one of several ligands triggers a series of proteolytic cleavages that release the intracellular region of Notch from the membrane, allowing it ultimatel