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Notch receptor–ligand binding and activation: Insights from molecular studies

✍ Scribed by Chandramouli R. Chillakuri; Devon Sheppard; Susan M. Lea; Penny A. Handford

Book ID
116881787
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1008 KB
Volume
23
Category
Article
ISSN
1084-9521

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## Abstract The constitutive androstane receptor (CAR) possesses, unlike most other nuclear receptors, a pronounced basal activity __in vitro__ whose structural basis is still not fully understood. Using comparative molecular dynamics simulations of CAR X‐ray crystal structures, we evaluated the mo