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NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion

✍ Scribed by Baldoni, Stefano; Sportoletti, Paolo; Del Papa, Beatrice; Aureli, Patrizia; Dorillo, Erica; Rosati, Emanuela; Ciurnelli, Raffaella; Marconi, Pierfrancesco; Falzetti, Franca; Di Ianni, Mauro


Book ID
120511218
Publisher
Carden Jennings Publishing
Year
2013
Tongue
English
Weight
400 KB
Volume
98
Category
Article
ISSN
0925-5710

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Sustained NF-kappaB activity in chronic
✍ Lukas P. Frenzel; Rainer Claus; Nadine Plume; Janine Schwamb; Carolin Konermann; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 330 KB 👁 1 views

## Abstract Inappropriate nuclear factor (NF) κB activity is one major hallmark of B‐cell malignancies and chronic lymphocytic leukemia (CLL). NFκB‐dependent genes are involved in antiapoptosis, cell proliferation and metastasis and are responsible for survival and proliferation of tumors. However,