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Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway

✍ Scribed by Daniel P Stiehl; Wolfgang Jelkmann; Roland H Wenger; Thomas Hellwig-Bürgel


Book ID
117103865
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
334 KB
Volume
512
Category
Article
ISSN
0014-5793

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✍ Alain Mauviel; Nathalie Temime; Dominique Charron; Gérard Loyau; Jean-Pierre Puj 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 824 KB

It has previously been demonstrated that interleukin-1 (IL-I) is expressed in a variety of fibroblast cell lines. In this study, we investigated the mechanisms involved in the regulation of IL-1 p production by cultured human dermal fibroblasts. We have shown that IL-I p is constitutively expressed