Normalization of Striatal Tyrosine Hydroxylase and Reversal of Motor Impairment in Experimental Parkinsonism with Intravenous Nonviral Gene Therapy and a Brain-Specific Promoter

Intravenous glial-derived neurotrophic f

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

✍ Chun-Fang Xia; Ruben J. Boado; Yun Zhang; Chun Chu; William M. Pardridge 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB

## Abstract ## Background Rats with experimental Parkinson's disease (PD) are treated with intravenous glial‐derived neurotrophic factor (GDNF) plasmid DNA, non‐viral gene therapy using Trojan horse liposomes (THLs) targeted with a monoclonal antibody (MAb) to the rat transferrin receptor (TfR). E