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Normal oxidative activity and chemotaxis of circulating neutrophils in patients treated with photopheresis

โœ Scribed by N. Obel; M. Storgaard; B. Hansen; H. Zachariae

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
262 KB
Volume
286
Category
Article
ISSN
0340-3696

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โœฆ Synopsis

In photopheresis peripheral leukocytes are exposed to photoactivated 8-methoxypsoralen in an extracorporeal flow system. The present study was performed to characterize the effect of photopheresis upon the function of peripheral circulating neutrophils. Superoxide generating capacity and ehemotactie ability of peripheral circulating neutrophils were tested in seven patients immediately before and after treatment with photopheresis. Soperoxide generation stimulated by phorbol-12-myristate-13-aeetate and N-formyl-methionyMeucyl-phenylalanine (fMLP) and fMLP-induced chemotaxis were found not to be influenced by photopheresis. We conclude that circulating neutrophils obtained from patients treated with photopheresis possess normal superoxide-generating capacity and chemotactic ability.

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