Normal dopaminergic and serotonergic metabolites in cerebrospinal fluid and blood of restless legs syndrome patients
✍ Scribed by Karin Stiasny-Kolster; J. Carsten Möller; Johannes Zschocke; Oliver Bandmann; Werner Cassel; Wolfgang H. Oertel; Georg F. Hoffmann
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 234 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
Cerebrospinal fluid (CSF) and blood obtained from 22 untreated or scarcely treated patients with moderate to severe restless legs syndrome (RLS; mean age, 58.6 +/- 13 years) and 11 control subjects (mean age, 56.6 +/- 12.9 years) were investigated for biogenic amines between 6:00 and 8:00 PM. We did not find any significant differences in the CSF concentrations of homovanillic acid, 3-ortho- methyl-dopa, levodopa, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tetrahydrobiopterin, dihydrobiopterin, 5-methyltetrahydrofolate, and neopterin. In addition, serotonin in whole blood and plasma activity of aromatic amino acid decarboxylase were all normal. Our results suggest that dopaminergic and serotonergic release is not substantially affected in RLS.