Normal binding of plasma von Willebrand factor to platelets in essential thrombocythemia
β Scribed by van Genderen, Perry J.J.; Leenknegt, Henriette
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 84 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0361-8609
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π SIMILAR VOLUMES
Extensive microvascular platelet aggregation is characteristic of thrombotic thrombocytopenic purpura (TTP). Previous studies have indicated that abnormalities of von Willebrand factor (vWf) are often present in TTP patient plasma. There has not been previously any direct evidence linking these abno
Thrombotic thrombocytopenic purpura (TTP) is a disorder of systemic platelet aggregation. Evidence has accumulated that the aggregating agonist in TTP of all types is likely to be von Willebrand factor (vWf), especially unusually large vWf multimers derived from endothelial cells. Recent evidence in
We have studied the ability of the plasma to induce aggregation of both homologous and heterologous platelets in four patients with hemolytic-uremic syndrome (HUS) associated with chemotherapy with mitomycin C (MMC). Neither platelet aggregation was elicited by patients' plasmas nor the in vitro add