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Normal and variant transthyretin in a patient with familial amyloidotic polyneuropathy: DNA, mRNA, serum, and amyloid deposits

✍ Scribed by T. Uemichi; J.J. Liepnieks; R.P. Waits; M.D. Benson


Book ID
116168688
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
61 KB
Volume
6
Category
Article
ISSN
0960-8966

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Familial amyloidotic polyneuropathy is an inherited form of amyloidosis associated with a mutant form of a protein called transthyretin. The Methionine-30 variant is the most frequent mutation observed. This disorder is caused by deposition of this protein as amyloid in several organs, such as the h